DHEA (dehydroepiandrosterone) and pregnenolone are essential hormones that contribute to the production of all other hormones in the human body. Research indicates these substances may help reduce inflammation, support overall health, and potentially slow aging. Additionally, DHEA and pregnenolone play crucial roles in brain function. They facilitate communication between brain cells, adapt connections between them, and provide protection.
Dysregulation of these hormones is linked to conditions such as Alzheimer’s disease, schizophrenia, and epilepsy. Given their significance in brain health, neurosteroids could be promising targets for treating these disorders. These hormones are involved in various brain processes, including the formation of myelin (the protective covering of nerve fibers), supporting brain development, aiding in the maturation of brain cells, and reducing symptoms of anxiety and depression.
Furthermore, they can enhance memory. DHEA and pregnenolone may help preserve skin health and vitality for older adults facing age-related challenges. Their protective characteristics suggest they could also alleviate anxiety and depression, prevent seizures, and improve memory—an essential aspect of maintaining mental clarity and emotional well-being as we age.
Wang, M., Hu, S., Fu, X., Zhou, H., Yang, S., & Yang, C. (2024). Neurosteroids: A potential target for neuropsychiatric disorders. The Journal of Steroid Biochemistry and Molecular Biology, 106485.
